Amano Jyaku, a mischievous, sociopathic demon/human hybrid, is banished to Earth and ordered by The Great Elder to find the Chōjin: the unbeatable god of the demon world who is hiding within the body of... a man.
A group of reptilian/amphibian demons want to find the Chōjin and use his power on behalf of the Queen of Demons. Under the leadership of Suikakuju, the Elder's rival and lover of his estranged wife, the Queen of Demons, they hatch a series of plots to try to capture the Chōjin, most of which go horribly wrong.
Amano is sent to protect the Chōjin, but after his lecherous friend Koroko and then later his nymphomaniac sister Megumi come to find him, this proves to be more difficult.